T-ARG-eting E2F-1 growth control
نویسندگان
چکیده
منابع مشابه
T-ARG-eting E2F-1 growth control
The transcription factor E2F-1 is an important regulator of cell fate, which is able to promote cell cycle progression and DNA repair, but also drive p53-dependent and -independent apoptosis. Accordingly, E2F-1 has been reported to have both tumor-suppressive and oncogenic properties. For example, E2F-1 mice suffer from an increased susceptibility to tumor formation, which is consistent with a ...
متن کاملArginine methylation-dependent reader-writer interplay governs growth control by E2F-1.
The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. Methylation by PRMT1 hinders methyl...
متن کاملArginine methylation controls growth regulation by E2F-1.
E2F transcription factors are implicated in diverse cellular functions. The founding member, E2F-1, is endowed with contradictory activities, being able to promote cell-cycle progression and induce apoptosis. However, the mechanisms that underlie the opposing outcomes of E2F-1 activation remain largely unknown. We show here that E2F-1 is directly methylated by PRMT5 (protein arginine methyltran...
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Thrombospondin 1 (TSP1) has been shown to play a critical role in inhibiting angiogenesis, resulting in inhibition of tumor growth and metastases. To figure out TSP1's regulators will lead to reveal its biological function mechanistically. In this study, we show that E2F-1 could activate the transcription of TSP1 by both promoter assays and Northern blot. Analysis of various TSP1 promoter mutan...
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E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. Interaction between pRB and E2F-1 is dependent on the phosphorylation status of pRB. Despite the fact that E2F-1 and pRB have antagonistic activities when they are overexpressed, the role of the E2F-1-pRB interaction in cell growth largely remains unknown. Ideally, it would be better to study the proper...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.21467